An essential role for Rab27a GTPase in eosinophil exocytosis
نویسندگان
چکیده
منابع مشابه
Rac GTPase plays an essential role in exocytosis by controlling the fusion competence of release sites.
The role of small GTPases of the Rho family in synaptic functions has been addressed by analyzing the effects of lethal toxin (LT) from Clostridium sordellii strain IP82 (LT82) on neurotransmitter release at evoked identified synapses in the buccal ganglion of Aplysia. LT82 is a large monoglucosyltranferase that uses UDP-glucose as cofactor and glucosylates Rac (a small GTPase related to Rho), ...
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Because mutations in Rab27a have been linked to immune defects in humans, we have examined cytotoxic lymphocyte function in ashen mice, which contain a splicing mutation in Rab27a. Ashen cytotoxic T lymphocytes (CTLs) showed a >90% reduction in lytic activity on Fas-negative target cells compared with control C3H CTLs, and ashen natural killer cell activity was likewise diminished. Although the...
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15 صفحه اول–sensing Module Essential for Exocytosis
The synaptic vesicle protein synaptotagmin I has been proposed to serve as a Ca 2 1 sensor for rapid exocytosis. Synaptotagmin spans the vesicle membrane once and possesses a large cytoplasmic domain that contains two C2 domains, C2A and C2B. Multiple Ca 2 1 ions bind to the membrane proximal C2A domain. However, it is not known whether the C2B domain also functions as a Ca 2 1 -sensing module....
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ژورنال
عنوان ژورنال: Journal of Leukocyte Biology
سال: 2013
ISSN: 0741-5400
DOI: 10.1189/jlb.0812431